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Contact

Language Skills

Python
R
Bash
Visual Basic

Disclaimer

Made with the R package pagedown.

The source code is available on github.com/nstrayer/cv.

Last updated on 2020-07-08.

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Kyle T Helzer, Ph.D. 

Experienced scientist interested in the analysis of large data sets to solve biological problems. My doctoral research involved investigating the genome-wide binding profile of phosphorylated estrogen receptor-a in a human breast cancer cell line. Strong background and understanding of both wet lab (molecular biology, CRISPR, cell culture, PCR) and dry lab (Linux, Python, R) skill sets.

Research Experience

Postdoctoral Researcher

Proteovista LLC

Madison, WI

current - 2019

  • Lead and performed research and development on novel array-based technology
  • Developed algorithms for DNA and protein array generation

Graduate Student

Alarid Laboratory

University of Wisconsin - Madison

2019 - 2013

  • Analyzed the genome-wide binding profile of the phosphorylated estrogen receptor-alpha in the MCF-7 breast cancer cell line via ChIP-seq
  • Built custom python algorithm for analysis of bedgraph files
  • Utilized R and ggplot2 for data analysis and figure design

Research Assistant

Olsen Laboratory

University of Michigan

2013 - 2010

  • Worked in the laboratory of Dr. Laura Olsen on peroxisomal protein import and processing in Arabidopsis thaliana. As an undergraduate, I planned and performed my own experiments and projects as well as analyzed the data.
  • Trained and mentored new undergraduate researchers.

Education

Ph.D., Cancer Biology

University of Wisconsin - Madison

Madison, WI

2019 - 2013

  • Thesis: Effects of Phosphorylation on the DNA Binding Properties of Estrogen Receptor-alpha
  • Advisor: Elaine T. Alarid, Ph.D.

B.S. (with honors), Cellular and Molecular Biology

University of Michigan

Ann Arbor, MI

2012 - 2008

  • Honors Thesis: Processing of Citrate Synthase by the Peroxisomal Protease DEG15 in Arabidopsis thaliana
  • Advisor: Laura J. Olsen, Ph.D.
  • Minor in music

Publications

The phosphorylated estrogen receptor a cistrome identifies a subset of active enhancers enriched for direct ER-DNA binding and the transcription factor GRHL2

Molecular and Cellular Biology

N/A

2019

  • Helzer KT, Szatkowski Ozers M, Meyer MB, Benkusky NA, Solodin N, Reese RM, Warren CL, Pike JW, and Alarid, ET (2019). The Phosphorylated Estrogen Receptor a (ER) Cistrome Identifies a Subset of Active Enhancers Enriched for Direct ER-DNA Binding and the Transcription Factor GRHL2. Mol. Cell. Biol. 39.

17ß-Estradiol and ICI182,780 Differentially Regulate STAT5 Isoforms in Female Mammary Epithelium, With Distinct Outcomes

Journal of the Endocrine Society

N/A

2018

  • Jallow F, Brockman JL, Helzer KT, Rugowski DE, Goffin V, Alarid ET, and Schuler LA (2018). 17ß-Estradiol and ICI182,780 Differentially Regulate STAT5 Isoforms in Female Mammary Epithelium, With Distinct Outcomes. J Endocr Soc 2, 293–309.

Ubiquitylation of nuclear receptors: new linkages and therapeutic implications

Journal of Molecular Endocrinology

N/A

2015

  • Helzer KT, Hooper C, Miyamoto S, and Alarid ET (2015). Ubiquitylation of nuclear receptors: new linkages and therapeutic implications. J. Mol. Endocrinol. 54, R151-167.

Teaching Experience

I am passionate about education. I believe that no topic is too complex if the teacher is empathetic and willing to think about new methods of approaching task.

Oncology 675 - Readings in Cancer Biology

University of Wisconsin - Madison

Madison, WI

2015

  • Served as a TA for graduate level course on how to critically evaluate scientific literature
  • Course Instructor: Dr. Bill Sugden

Honors and Awards

Cancer Biology Training Grant

NIH T32 award for training in cancer biology

UW-Madison

2017 - 2015

University Honors

For earning above a 3.5 GPA

University of Michigan

2012 - 2008

James B. Angell Scholar

For earning all As in a semester

University of Michigan

2011 - 2010

Regents Scholarship

For outstanding academic achievement

University of Michigan

2008

Presentations

Genome-Wide Binding Profile of Phosphorylated Estrogen Receptor Reveals Association with Direct DNA Binding

ENDO 2019

New Orleans, LA

2019

Investigating the Effects of Phosphorylation on the DNA Binding Properties of ERa

McArdle Student Seminar Series

UW-Madison

2018

Investigating the Effects of Phosphorylation on the DNA Binding Properties of ERa

McArdle Student Seminar Series

UW-Madison

2018

Investigating the Effects of Phosphorylation on the DNA Binding Properties of ERa

McArdle Student Seminar Series

UW-Madison

2017

Investigating the Effects of Phosphorylation on the DNA Binding Properties of ERa

O’Brien Symposium

Madison, WI

2017

Investigating the Role of Phosphorylation on the DNA Binding Properties of ERa

McArdle Student Seminar Series

UW-Madison

2016

Insights into Estrogen Receptor-alpha Phosphorylation

McArdle Student Seminar Series

UW-Madison

2015

Posters

Defining the Phosphorylated ERa Cistrome

Gordon Research Conference on Hormone Dependent Cancers

Newry, ME

2017

Analysis of the Phosphorylated ERa Cistrome with Multiple pS118-ER Specific Antibodies

7th Great Lakes Nuclear Receptor Conference

Cleveland, OH

2016

The Elephant in the Room

McArdle 75th Anniversary Open House

UW-Madison

2014

Processing of the Peroxisomal Protease DEG15 in Arabidopsis thaliana

MCDB Honors Research Symposium

University of Michigan

2012

Conferences Attended

ENDO 2019

Morial Convention Center

New Orleans, LA

2019

8th Great Lakes Nuclear Receptor Conference

University of Minnesota

Minneapolis, MN

2018

Gordon Research Conference on Hormone Dependent Cancers

Sunday River Resort

Newry, ME

2017

O’Brien Symposium

University of Wisconsin - Madison

Madison, WI

2017

7th Great Lakes Nuclear Receptor Conference

Case Western Reserve University

Cleveland, OH

2016

McArdle 75th Anniversary Symposium on Cancer

University of Wisconsin - Madison

Madison, WI

2015

6th Great Lakes Nuclear Receptor Conference

University of Wisconsin - Madison

Madison, WI

2014